When you cook pork tenderloin in the oven, one of the most important factors for ensuring delicious and juicy results is to know how long to cook it. Knowing when your pork tenderloin is fork-tender not only guarantees optimal taste but also prevents food safety issues due to undercooking. In this blog post, we’ll be exploring how long to cook pork tenderloin in oven at 400 — plus some handy tips on preparing and seasoning your succulent protein.
What is pork tenderloin?
Pork tenderloin is a lean, juicy cut of meat that comes from the muscle located along the backbone of a pig. It’s one of the most versatile cuts to work with since it takes well to grilling, roasting and sautéing. It has very little fat compared to other pork cuts but provides plenty of flavor when cooked properly.

Nutritional facts of pork tenderloin
Pork tenderloin is an excellent source of protein, vitamins B6 and B12, thiamin, riboflavin and niacin. It provides complete lean nutrition with 15 grams of fat per 100-gram serving.
What is the best temperature to cook pork tenderloin in the oven?
When cooking pork tenderloin in the oven, you should use a temperature of 400°F. This high-heat is necessary to create an outer crust while still preventing the center from drying out. It’s also important to preheat your oven so that it reaches the desired temperature before you start cooking.
How long to cook pork tenderloin in oven at 400?
Cooking time will vary depending on how thick your pork tenderloin is, but generally speaking, you’ll want to roast it for 25-30 minutes at a temperature of 400 degrees Fahrenheit (204 degrees Celsius). A good rule of thumb is to cook it for 10-15 minutes per pound (454 g).
To check if the pork is cooked right, you can use an instant-read thermometer. Insert it into the thickest part of the tenderloin and look for an internal temperature of 145°F (63°C). Once it reaches that temperature, take the pork out of the oven and allow it to rest for 10 minutes before carving.

Why to cook pork tenderloin In oven at 400 for so long?
Cooking pork tenderloin at 400°F allows you to get a golden, crispy exterior on your pork while still keeping the inside juicy and tender. The high temperature also helps bring out some amazing flavors that are inherent in pork. The longer cooking time ensures that the meat is cooked through completely, which helps ensure food safety.
How to cook pork tenderloin in oven at 400?
To ensure juicy and flavorful results, it’s important to season the tenderloin with salt and pepper before cooking. If you want to add extra flavor, you can brush some olive oil onto the pork and sprinkle your favorite herbs or spices overtop.
Once seasoned, place the tenderloin in a roasting pan or baking sheet, making sure that the thickest part of the pork is facing up. Bake in the preheated oven for 25-30 minutes or until the internal temperature reaches 145°F (63°C).
Once cooked, take the pork out of the oven and allow it to rest for 10 minutes before carving. This will ensure that all the flavors and juices are locked in, resulting in a succulent and delicious meal.
We hope this blog post has been helpful in teaching you how long to cook pork tenderloin in oven at 400! With these simple tips and guidelines, your next pork dish will be sure to impress.
How to tell if pork tenderloin is cooked?
The easiest way to tell when your pork tenderloin is cooked through is to use a meat thermometer. Insert the thermometer into the thickest part of the pork and wait for it to reach an internal temperature of 145°F (63°C). If it has reached this temperature, it’s safe to remove from the heat and let it rest for 10 minutes before carving.
Another way to tell if the pork is cooked right is to cut into it. If you see any pink or red in the center, then it needs more time in the oven.
5 common mistakes when making pork tenderloin in the oven at 400?
1. Not preheating the oven: Preheating your oven is essential for a well-cooked pork tenderloin. Make sure to turn on the oven before you begin cooking and let it reach 400°F (204°C) before putting in the pork.
2. Overcooking or undercooking: To make sure the pork tenderloin is cooked through, use an instant-read thermometer to check its internal temperature. It should reach 145°F (63°C).
3. Using too much salt: Pork tends to absorb a lot of salt as it cooks, so start with less than you think you’ll need and adjust later if necessary.
4. Not letting the meat rest: After removing the pork from the oven, allow it to rest for 10 minutes before carving. This helps lock in all those delicious juices and flavor.
5. Not seasoning the pork: To get that extra layer of flavor, season your pork with salt and pepper before cooking and rub some olive oil over it. You can also add your favorite herbs and spices for more taste.

Tips to remember when cooking pork tenderloin
– Make sure your pork is thoroughly defrosted before you start cooking.
– Pat dry with paper towels, as this will help create a nice crisp crust for the outside of your pork.
– Preheat the oven before you start cooking your pork, as this will help it cook evenly.
– Use an instant-read thermometer to check the internal temperature of your pork to ensure that it’s cooked through.
– Allow the pork to rest for 10 minutes once it’s been cooked. This helps keep all the juices in the pork and make it more tender.
By following these tips, you’ll be well on your way to creating a perfectly cooked pork tenderloin every time! With just a few simple steps, you can enjoy succulent, juicy pork that’s packed with flavor.
Some recipe with pork tenderloin cooked in oven at 400
– Garlic Herb Roast Pork Tenderloin: Rub a pork tenderloin with garlic, herbs, and olive oil before roasting it in a 400°F (204°C) oven for 25-30 minutes. This garlicky dish pairs perfectly with mashed potatoes or roasted vegetables.
– BBQ Pork Tenderloin: Mix together your favorite barbecue sauce and brush it over a pork tenderloin before roasting in the oven at 400°F (204°C). The result is a sweet, smoky, and tangy meal that’s sure to please.
– Mustard-Glazed Pork Tenderloin: Mix together Dijon mustard and honey for a sweet-tangy glaze, brush it over a pork tenderloin, and then roast in the oven at 400°F (204°C). The result is a flavorful entree that’s full of zesty flavor.
– Spice Rubbed Pork Tenderloin: Make a spice rub using your favorite spices, such as cumin, coriander, and chili powder. Rub it over the pork tenderloin before roasting in the oven at 400°F (204°C). The result is an aromatic dish that’s perfect for dinner parties or weeknight meals.

No matter how you choose to prepare your pork tenderloin, it’s sure to be a delicious dish that everyone will love! So don’t let the how-tos overwhelm you — just remember these key tips for how long to cook pork tenderloin in oven at 400°F (204°C) and you’ll be on your way to cooking perfection.
What to serve with pork tenderloin?
The possibilities for sides to serve with your pork tenderloin are endless! Here are some classic ideas:
– Roasted potatoes: Roast your favorite potatoes in the oven with some garlic and herbs for a flavorful side dish.
– Steamed vegetables: Steam some colorful veggies like carrots, green beans, or broccoli for a healthy accompaniment to your meal.
– Salad: Make a simple green salad with mixed greens, tomatoes, cucumbers, and your favorite dressing.
– Grilled vegetables: Grill some zucchini, eggplant, peppers, and onions for an easy yet delicious side.
– Rice or quinoa: Cook some white rice or quinoa to add a nutty flavor and texture to your meal.
Whichever sides you choose to serve with your pork tenderloin, they’ll be sure to complement the succulent flavor of your pork perfectly.

How to store leftovers with cooked pork tenderloin?
Once you’ve cooked your pork tenderloin, it’s important to store any leftovers properly. Allow the meat to cool completely before transferring it to an airtight container and storing it in the refrigerator for up to 4 days. Alternatively, you can cut the pork into slices or cubes and freeze for up to 2 months.
When you’re ready to enjoy the leftovers, warm them in a preheated oven at 350°F (176°C) for 10-15 minutes or until heated through. This will help ensure that the pork remains juicy and flavorful.
We hope this blog post has helped you learn how long to cook pork tenderloin in oven at 400 and how to store leftovers! With these tips, you’ll be sure to enjoy succulent and delicious pork every time.

Conclusion: How long to cook pork tenderloin in oven at 400
Cooking pork tenderloin in the oven at 400°F (204°C) is a great way to ensure it comes out juicy and tender. By following these tips, you can enjoy perfectly cooked pork every time — plus some delicious sides to accompany it! From how long to cook pork tenderloin in oven at 400°F (204°C) to how to store leftovers, now you’ll be an expert in preparing pork for the perfect meal.
FAQs Pork tenderloin
Is pork tenderloin better at 350 or 400?
For the peak pork experience, it pays to crank up the oven. Attaining an appealing outer crust and locking in that juicy flavor can be achieved by cooking your tenderloin at 400°F . But if you prefer something a little milder, 350° may be more suited to your taste buds. Either way – just don’t forget about those delicious juices.
Should pork tenderloin be cooked fast or slow?
For succulent results, lean pork tenderloin requires a different approach to cooking than more fatty roasts. Quickly searing it at high temperatures is the key for ultra-tender meat but overcooking will leave you with a chalky and chewy dish.
Can you overcook pork tenderloin?
Pork tenderloin is often unfairly judged as dry and flavorless, but this misconception only applies to those who don’t know that 145°F is the ideal internal temperature for pork. With proper cooking techniques you can ensure your dish will be succulent with a mouthwatering taste.
Should pork tenderloin be baked covered or uncovered?
This really depends on how you want your pork to turn out. If you’re aiming for something with a slight crispiness, then bake uncovered – but if you prefer your tenderloin soft and juicy, cover it with foil for the last portion of cooking time. Either way, the oven temperature should remain the same at 400°F. Lastly, always remember to let your pork rest at least 5 minutes before cutting and serving. This will help lock in all of the flavorful juices.
Should I wrap my pork tenderloin in foil?
Wrapping your pork tenderloin in foil is not necessary when baking it in the oven – but if you want to keep the heat and steam in, then go ahead. Just remember that this will affect how long it takes to cook so make sure to check the internal temperature of your pork accordingly.
How do you cook pork tenderloin so it’s not tough?
For tender, succulent pork that’s still juicy on the inside – keep it low and slow! Cooking at temperatures no higher than 350°F (176°C) for 25 minutes per pound will ensure each piece of meat becomes perfectly cooked without losing its moisture. Just make sure not to overcook; pink in the center is ideal. Perfection has never been easier!
How long does it take to cook a pork tenderloin at 375?
Fire up the oven and get ready for some deliciousness! Begin by placing a juicy pork tenderloin in the center of your baking dish. Then, give veggies an olive oil massage before sprinkling them with just enough salt to bring out their flavor. Gently lay these seasoned vegetables around your pork, then let it all bake until everything is roasted to perfection – about 30-45 minutes should do it (make sure you check that thermometer though!).
How long does it take to cook a pork tenderloin at 350 in the oven?
With oven-roasting or throwing it on the grill, you can make a delicious pork tenderloin in no time. Just place your loin in an uncovered baking dish and let it cook for between 20 to 27 minutes at 350°F! Enjoy succulent roast pork with minimal effort – yum.
Is it safe to cook pork tenderloin in the oven at 400?
Absolutely! It’s perfectly safe to cook your pork tenderloin in the oven at 400°F. Just make sure you use a reliable thermometer, as pork should be cooked to 145°F (63°C) for optimal safety and flavor. Be sure to let it rest after it’s done cooking – this will help keep all the juices in.
Can I cook pork tenderloin with vegetables?
If you’re looking for a tasty and nutritious dinner that comes together quickly, try roasting pork tenderloin with seasonal vegetables. Simply season the veg and arrange around the meat in an oven-safe dish – after 30-45 minutes your meal will be complete! Not only is it delicious but minimal clean up makes this double win even sweeter.
Susan Muskat is a professional chef with over 25 years of experience in the culinary industry. After working in some of the most prestigious restaurants in the world, she opened her own restaurant, Moose and Sadie’s, which quickly became a local favorite. Susan is also the author of a blog all about recipes, guidelines, cooking tips, and knowledge from professional chefs. She loves nothing more than sharing her passion for food with others.