Are you looking for the perfect meatloaf recipe? Struggling to get the baking time just right so your creation is succulent, juicy and full of flavor? Then you’ve come to the right place. We’re here to answer that very question: How long to cook a meatloaf at 375 degrees? Keep reading to learn all about how long it takes to get your perfectly cooked masterpiece onto the dinner table.
What is meatloaf?
Meatloaf is a traditional comfort food dish made from ground meat, often combined with other ingredients like breadcrumbs, onions, garlic and seasonings. It’s usually shaped into a loaf or similarly-shaped form, and then baked in the oven.

History of meatloaf
The earliest meatloaf recipes date back to the 5th century, when Roman cooks prepared a dish made from minced pork, beef and spices. Similar dishes were popular in other parts of Europe during the Middle Ages, often including dried fruit or nuts for flavor.
In North America, early settlers used whatever ingredients they had on hand to make their own local versions of the dish, which were often called “hashed meat”. Today there are many variations of the dish all over the world – each one as unique and delicious as the next.
Different types of meatloaf
Meatloaf can be made with almost any type of ground meat – beef, pork, lamb, chicken or turkey. Some recipes also call for combining two or more types of meat for a unique flavor and texture. You can also experiment with adding different ingredients like vegetables, herbs and spices to the mixture to create your own signature dish.
Nutritional information of meatloaf
Meatloaf is a great source of protein, as well as B vitamins and minerals like iron, zinc and selenium. Depending on the ingredients used, it can also contain healthy fats that are beneficial for heart health. However, it’s important to note that some recipes may be high in fat or sodium, so be sure to check the nutritional information before serving.
Pros and cons of store-bought vs homemade options meatloaf
There are pros and cons to both homemade and store-bought options when it comes to meatloaf. Homemade recipes provide more control over the flavors, but they can be time consuming and require additional ingredients. Store-bought versions are convenient, but may contain additives or preservatives that you’d rather avoid.

What temperature to cook meatloaf?
For the perfect meatloaf, you should always cook it at a temperature of 375 degrees Fahrenheit. It’s important to note that different types of ground meats may require slightly different cooking times, so use a food thermometer to check that the internal temperature has reached 165 degrees Fahrenheit before serving.
Why 375 degrees is ideal for a juicy and flavorful meatloaf?
Cooking your meatloaf at 375 degrees is the ideal temperature for achieving a juicy, flavorful dish. The high heat helps to seal in the juices of the meat and prevents it from drying out during baking. It also ensures that your ingredients are cooked through properly so they create an even flavor throughout.
How long to cook a meatloaf at 375?
Now know the answer to our main question: How long to cook a meatloaf at 375 degrees? The general rule of thumb is that it takes about 45 minutes to 1 hour for a 1.5 to 2 pound loaf. However, it’s always best to check the internal temperature of the meatloaf with a food thermometer to make sure it is cooked through.
What factors affect the baking time of a meatloaf at 375?
There are several factors that can affect the baking time of a meatloaf at 375 degrees. Firstly, the type of meat used – beef generally takes longer to cook than chicken or turkey. Secondly, the size and shape of the loaf; a thick, large-sized loaf will take longer to bake than a thin, small one. Lastly, whether or not you’re using any fillings – adding cheese, vegetables and other ingredients can increase the baking time.
How to choose the right baking dish for meatloaf?
When it comes to choosing a baking dish for your meatloaf, it’s important to make sure you choose one that is the correct size. A pan that is too big can cause the edges of the loaf to dry out, while a pan that is too small can cause it to spill over and create an uneven cook. It’s also important to note that metal pans generally conduct heat more quickly than glass or ceramic, so they can decrease the baking time slightly.
How to cook a meatloaf at 375?
Here’s a step-by-step guide for how to cook the perfect meatloaf at 375 degrees:
- Preheat your oven to 375 degrees Fahrenheit.
- Combine ground beef, breadcrumbs, eggs, garlic and onions in a large bowl. You can also add any other ingredients you like such as cheese or vegetables.
- Shape the mixture into a loaf shape and place it on a baking sheet lined with parchment paper.
- Bake for 45 minutes to 1 hour, until the internal temperature has reached 165 degrees Fahrenheit (check with a food thermometer).
- Let rest for 10 minutes before slicing and serving.

What happen if you cook meatloaf at a lower temperature?
Cooking your meatloaf at a lower temperature than 375 degrees can result in an undercooked and dry dish. The lower heat won’t allow the juices to be sealed in properly, which will cause the texture to suffer. It’s also important to note that cooking the loaf at too low of a temperature can also lead to foodborne illness, so it’s best to stick with the recommended 375 degrees.
Tips for making your meatloaf tastier and moister at 375 degrees
Now know how long to cook a meatloaf at 375 degrees, here are some tips for making it even tastier and moister:
- Add a glaze. Mix together ketchup, honey and Worcestershire sauce, then brush the mixture over the top of the meatloaf before baking.
- Use fresh herbs for extra flavor; try adding basil, oregano or thyme to your meatloaf mixture.
- Add a bit of moisture by mixing in grated carrots, zucchini or mushrooms to the mixture before baking.
- Let your cooked meatloaf rest for 10 minutes before slicing and serving – this will help keep it moist and juicy.
How to serve your perfectly cooked meatloaf at 375?
Now that you’ve got the perfect meatloaf, it’s time to serve it up. Here are some ideas for how to make your dish even more delicious:

- Serve with mashed potatoes or mac and cheese for a classic comfort food dinner.
- Add a side of roasted veggies or a fresh salad for a nutritious accompaniment.
- Top with your favorite condiments like BBQ sauce, ketchup or hot sauce.
- Make it into sandwiches – serve the meatloaf on buns with lettuce and tomatoes for a delicious lunch or dinner option.
- Enjoy with a glass of your favorite red or white wine.
Some recipe using meatloaf as an ingredient
Once you’ve mastered the basics of cooking a meatloaf at 375 degrees, why not take it up a notch and try using it in other dishes? Here are some ideas for recipes that use cooked meatloaf as an ingredient:
- Meatloaf lasagne – Layer cooked meatloaf with lasagna sheets and cheese sauce for a tasty twist on the classic dish.
- Meatloaf burgers – Add some cooked meatloaf to hamburger patties for a juicy burger that’s sure to please.
- Meatloaf tacos – Break up cooked meatloaf and use it as a filling for tacos. Top with cheese, salsa and guacamole for an easy dinner.
- Meatloaf macaroni and cheese – Break up cooked meatloaf and mix into macaroni and cheese for a hearty meal.
- Meatloaf pizzas – Top mini pizzas with cooked meatloaf, cheese and your favorite toppings for an easy appetizer or snack.
- Meatloaf stuffed mushrooms – Stuff mushroom caps with cooked meatloaf and cheese for a tasty starter or side dish.
- Meatloaf meatballs – Roll cooked meatloaf into balls and bake for a fun twist on traditional meatballs. Serve with your favorite sauce or add to your favorite pasta dish.

How to store leftover cooked meatloaf at 375?
If you have any leftovers from your cooked meatloaf, store them in an airtight container in the refrigerator. They will stay fresh for up to 3 days and can be reheated in the microwave or oven. You can also freeze cooked meatloaf – just make sure to wrap it tightly with plastic wrap before placing it in a freezer-safe container. It will stay fresh for up to 3 months. To reheat, simply thaw in the refrigerator overnight and then heat through in the oven or microwave.
Conclusion: How long to cook a meatloaf at 375
Cooking a meatloaf at 375 degrees Fahrenheit is the best way to achieve juicy, flavorful results. While it generally takes about 45 minutes to 1 hour for a 1.5 to 2 pound loaf, always use a food thermometer to make sure it’s cooked through before serving. Once you’ve mastered this technique, try experimenting with different recipes using cooked meatloaf as an ingredient. From lasagne to tacos, the possibilities are endless. With the right temperature and technique, you’ll be sure to create delicious dishes every time.
FAQs Meatloaf
How long does a 2lb meatloaf take at 350?
1 lb of meatloaf bakes in 45-60 minutes at 350 degrees. And for a 2 lb meatloaf, it takes about 1-1.5 hours in a regular oven. Enjoy a perfectly cooked and safe meal.
What is the secret to moist meatloaf?
Boost the flavor and juiciness of your meat by including eggs, ketchup, tomato paste, mustard, Worcestershire, barbecue sauce, or a tantalizing mix of wet seasonings. These ingredients are not only essential for enhancing taste and texture, but they also ensure your meat is irresistibly juicy. Don’t miss out on these game-changing additions.
Do you cover meatloaf with foil?
Yes, achieve a perfectly browned meatloaf with this cooking tip. To prevent burning, cover the meatloaf with foil for 45 minutes, then uncover it for the final 15 minutes. Get ready for a deliciously golden finish.
How full should my meatloaf pan be?
Ensure the meatloaf is positioned so that it is about 1/2 inch below the rim of the pan, to prevent grease from overflowing. For extra precaution, place the meat loaf pan on a cookie sheet to catch any potential grease spills.
Why is my meatloaf heavy?
A heavy meatloaf could be a sign of overmixing. Avoid this by only mixing together the ingredients until just combined, and don’t forget to mix in the right amount of liquid too. Too much liquid can make your meatloaf dense and heavy, so try sticking to the recipe’s recommended amounts for best results.
Can you cook meatloaf at 400?
Yes, cooking a meatloaf at 400 degrees increases the risk of it drying out, so keep an eye on it and check the internal temperature using a food thermometer. Generally, you can expect to cook your meatloaf in about 40-45 minutes at this temperature. Be sure to let it rest for 10 minutes before slicing and serving.
Why milk instead of water in meatloaf?
Boost the juiciness of your meatloaf with a secret ingredient: milk. As it soaks into the bread crumbs, it infuses your meatloaf with essential moisture. Don’t fancy milk? No worries. Opt for low sodium beef stock, chicken stock, water, or even a non-dairy milk substitute instead.
Why is my meatloaf mushy and falling apart?
Mastering the perfect meatloaf can be a challenge. The key is to find the right balance between moisture and binders. Too much liquid or add-ins can cause it to fall apart, while not enough binder leaves it dry and tough. Achieving a soft and tender loaf that holds together requires finesse and precision.
Should you put bread under meatloaf?
Discover the secret to leaner, tastier homemade meatloaf with this easy trick. Simply line your pan with slices of bread before adding the meat mixture. As it bakes, the bread will ingeniously soak up the excess grease, leaving you with a healthier dish without sacrificing any flavor.
Should meatloaf touch the sides of the pan?
No. Create an appealing loaf shape with your hands, just like a real loaf of bread. Be careful not to let the meat touch the sides of the pan. This will result in a beautifully browned meatloaf on all sides and the fat will have the space to drain away from the meat.
Susan Muskat is a professional chef with over 25 years of experience in the culinary industry. After working in some of the most prestigious restaurants in the world, she opened her own restaurant, Moose and Sadie’s, which quickly became a local favorite. Susan is also the author of a blog all about recipes, guidelines, cooking tips, and knowledge from professional chefs. She loves nothing more than sharing her passion for food with others.